Decreased ovarian function after 40 is a natural process, but in some women it happens earlier than expected. This may be due to perimenopause, premature ovarian failure (POF), or hormonal imbalances.
1. Symptoms of decreased ovarian function
🔹 Gynecological and reproductive symptoms:
✅ Irregular menstrual cycle (shortening, lengthening, missed periods).
✅ Scanty or, conversely, heavy menstruation.
✅ Lack of ovulation (can be determined by ovulation tests, BT chart).
✅ Decreased fertility (difficulty conceiving).
🔹 Hormonal changes and general well-being:
✅ Hot flashes, night sweats.
✅ Increased fatigue, weakness.
✅ Irritability, mood swings, depression.
✅ Decreased libido.
🔹 External signs:
✅ Dry skin, brittle hair and nails.
✅ Weight gain, especially in the waist area.
✅ Dry mucous membranes (eyes, vagina).
2. Tests indicating decreased ovarian function
🔹 Hormonal tests:
📌 FSH (follicle-stimulating hormone) – if high (>10-12 mIU / ml), this indicates a decrease in ovarian reserve.
📌 LH (luteinizing hormone) – increases with decreased ovarian function.
📌 AMH (anti-Müllerian hormone) – if <1.0 ng / ml, this indicates low ovarian reserve.
📌 Estradiol (E2) – if low (<30-50 pg/ml), this is a sign of ovarian failure.
📌 Prolactin – its high level can suppress ovulation.
📌 Testosterone and DHEA-S – a decrease in these hormones may indicate a decrease in ovarian activity.🔹 Additional tests:
📌 Ovarian ultrasound – decreased ovarian size, low antral follicle count (<5-7 in each ovary).
📌 Inhibin B test – if low, this also indicates a decrease in reserve.
📌 Thyroid hormones (TSH, T3, T4) – hypothyroidism can mimic menopause symptoms.
Ovarian rejuvenation after 40 is a hot topic for women who want to improve fertility, extend their reproductive age, or reduce the symptoms of hormonal deficiency. There are several methods aimed at restoring ovarian function, improving egg quality, and stimulating hormonal activity.
Main methods of ovarian rejuvenation
1. PRP therapy (ovarian plasma therapy)
🔹 The essence of the method: the introduction of platelet-rich plasma (PRP) into ovarian tissue to stimulate regeneration.
🔹 How it works:
Improves blood supply to the ovaries.
Stimulates the growth of new follicles.
Can promote the production of your own hormones.
🔹 Who it suits: women with low ovarian reserve, early menopause before 40 years, problems with ovulation.
🔹 Results: improved ovulation is noted in some women.
2. Stem cells
🔹 The essence of the method: the introduction of your own or donor stem cells into the ovaries.
🔹 How it works:
Promotes the regeneration of ovarian tissue.
Potentially increases the number of active follicles.
🔹 The results are promising and effective even for women after 40 years.
3. Hormonal therapy (HRT, bioidentical hormones)
🔹 The essence of the method: replenishment of the lack of estrogen and progesterone, androgen, etc.
🔹 How it works:
Improves overall well-being.
Helps stabilize the menstrual cycle.
🔹 Cons: does not restore ovarian reserve, but only compensates for the lack of hormones.
4. Mitochondrial therapy (OMT, Augment technology)
🔹 The essence of the method: transplantation of mitochondria from a woman’s young cells into her own eggs.
🔹 How it works:
Improves the energy potential of eggs.
Increases the likelihood of successful conception.
🔹 Used in a small number of clinics
5. Diet and nutritional support
🔹 Omega-3, coenzyme Q10, vitamin D, magnesium – improve hormonal balance and egg quality.
🔹 Antioxidants (resveratrol, curcumin) – protect the ovaries from age-related changes.
🔹 Low glycemic index diet – helps stabilize insulin levels, which affect fertility.
In our treatment practice, we use the following treatment methods:
STEM CELLS FOR OVARY REJUVENATION
The use of endometrial and endothelial stem cells is a promising direction in regenerative medicine for restoring reproductive function. These cells have a high capacity for tissue renewal, improving blood supply and stimulating the growth of new cells in the ovaries and endometrium.
1. Endometrial stem cells (eMSCs) in reproductive medicine
📌 What is it?
Endometrial stem cells are found in the uterine mucosa (endometrium) and are able to regenerate endometrial tissue after each menstrual cycle.
📌 How can they help?
Restoration of the endometrium in chronic endometritis, Asherman’s syndrome (intrauterine adhesions).
Improving embryo implantation during IVF.Possible ovarian stimulation – studies show that eMSCs can activate dormant follicles.
📌 How are they administered?
Intrauterine administration (injection or capsule with cells).
Donor cells.
2. Endothelial stem cells to improve ovarian blood supply
📌 What is it?
Endothelial cells are the precursors of cells that form blood vessels. They are found in bone marrow and peripheral blood.
📌 How can they help?
Improve blood circulation in the ovaries, which is important in cases of ovarian depletion.
Promote follicle restoration by improving the delivery of oxygen and nutrients.
Used for low ovarian reserve and premature ovarian failure syndrome (POF).
📌 How are they administered?
Intravenous injections.
Perfusion through the uterine vessels.
📌 Where is it used?
3. Possible prospects and limitations
✅ Pros:
Possibility of natural restoration of reproductive function.
Minimal invasiveness.
❌ Cons:
High cost of procedures.
Individual effectiveness (not 100% result for all women).
BIOIDENTICAL HORMONES IN RISING REPRODUCTIVE FUNCTION
Bioidentical hCG to improve reproductive function
Human chorionic gonadotropin (hCG) is a hormone that plays a key role in supporting pregnancy, but can also be used to improve ovarian function, stimulate ovulation and increase progesterone levels.
1. How does hCG affect reproductive function?
✅ Stimulates ovulation – used in IVF protocols and infertility treatment.
✅ Supports the luteal phase – helps the body produce more progesterone, reducing the risk of miscarriage.✅ Increases the sensitivity of the ovaries to FSH and LH – can help improve the quality of eggs.
✅ Helps with reduced ovarian function – used for premature ovarian failure (POF) and late reproductive age.
2. In what cases is bioidentical hCG prescribed?
📌 With a lack of LH and FSH (for example, with hypothalamic amenorrhea).
📌 To induce ovulation (most often as part of IVF or when stimulating natural conception).
📌 With low progesterone – hCG stimulates the corpus luteum to produce more progesterone.
📌 To support pregnancy in the first trimester – especially in women with habitual miscarriage.
3. Forms and methods of application
🔹 Bioidentical hCG in pellet form
MITOCHONDRIAL THERAPY IN OVARY REGENERATION
Mitochondrial therapy (OMT – Oocyte Mitochondrial Transfer) is an innovative method aimed at improving the quality of eggs by restoring their energy potential.
🔹 Why is it important?
After 35–40 years, mitochondria in eggs lose their effectiveness, which leads to:
Poor cell division,
Increased number of abnormalities in embryos,
Low implantation rate,
High risk of miscarriage.
1. How does mitochondrial therapy work?
✅ Healthy mitochondria are isolated from the young cells of a woman or donor.
✅ Energy production (ATP) improves, the chance of success increases