Stem Cell Therapy Of Development Delay Diseases – Patient Reviews & Outcomes

OUR CLINIC'S APPROACH IN TREATMENT DEVELOPMENT DELAY DISEASES

Developmental delay is the failure of a child to meet certain developmental milestones, such as sitting, walking and talking, at the average age. Developmental delays may indicate a problem in the development of the central nervous system. The child’s mental development is delayed, leading to poor motor and communication skills. Such children catch up to standard development milestones later than normal children.

Our working experience is 22 years and we has treated a large number of children from all over the world. Improvements were reported in most cases.

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For optimal effect, it is important to start stem cell treatment with your child as early as possible, while the brain is still developing.

Combined treatment involving routine therapy and stem cells results in a number of improvements:

cognitive improvements;
easier contact with the child, starting with eye contact;
improved verbal skills. If the child was non-verbal, it is very likely to start making sounds, produce syllables and eventually pronounce words; verbal children are likely to expand their vocabulary;
better learning capacity;
improved information processing, such as memory, including memorization and storage, information processing and recall;
greater self-confidence. Child feels more protected, less vulnerable, and exposure to the environment does not cause negative emotions;
improved social adaptation;
better self-care skills;
boosted immunity.

The advantages of our method are:

lack of side effects;
no chemicals involved;
minimally invasive procedure (IV infusions and injections);
no rejection risk;
no cancer risk;

Stem Cell–Based Treatment for Developmental Delay Conditions:

Induced pluripotent stem cells (iPSCs) have emerged as one of the most promising tools in regenerative neuroscience for addressing developmental delay. iPSCs are adult cells that have been reprogrammed to an embryonic-like state, allowing them to differentiate into various neural cell types. In experimental and early clinical research, iPSCs can be guided to become neurons, glial cells, and neural progenitors that may help replace or support underdeveloped or damaged neural networks associated with developmental disorders. Their key advantage is that they can be generated from a patient’s own cells, potentially reducing immune rejection and improving compatibility with the developing nervous system.

Neural cells derived from stem cells, including neuroblasts, axons, and oligodendrocytes, play distinct but interconnected roles in brain repair and development. Neuroblasts act as immature neurons that can migrate to areas of injury or underdevelopment and mature into functional nerve cells. Axons, which are the long projections of neurons, are essential for transmitting electrical signals across different brain regions. Oligodendrocytes produce myelin, the protective sheath that surrounds axons and enhances signal speed and efficiency. After stem cell-based interventions, researchers observe increased axonal growth, improved myelination, and better neural connectivity, which may support cognitive, motor, and sensory development.

Neural exosomes have recently gained attention as a cell-free therapeutic approach for developmental delay. Exosomes are tiny vesicles released by cells that contain proteins, lipids, and genetic material such as microRNAs. Neural-derived exosomes can cross the blood-brain barrier and deliver signaling molecules that promote neuroprotection, reduce inflammation, and stimulate neural repair. Instead of replacing cells directly, exosomes work by modifying the brain’s microenvironment, encouraging existing neurons to grow, form new synapses, and function more effectively.

At the cellular and biochemical level, stem cell and exosome-based therapies are associated with several structural and metabolic changes in the nervous system. These include increased synaptic density, enhanced neuroplasticity, and improved mitochondrial function within neurons, leading to better energy production. Biochemically, there is often a reduction in pro-inflammatory markers, an increase in neurotrophic factors such as BDNF (brain-derived neurotrophic factor), and improved neurotransmitter balance. Together, these changes may support more efficient neural communication and developmental progress following therapy.

WHY STEM CELLS THERAPY IS PROMISING FOR DEVELOPMENT DELAY DISEASES

Neurodevelopmental disorders such as autism spectrum disorder (ASD), Down syndrome, cerebral palsy, global developmental delay, and certain genetic or metabolic conditions have traditionally been treated with behavioral therapies, educational interventions, medications for symptoms, and supportive care. While these approaches are valuable, they do not address the underlying biological differences in brain development, neural connectivity, inflammation, or cellular dysfunction that often characterize these conditions. This is where stem cell therapy has emerged as one of the most exciting and rapidly advancing areas of medical research.

Stem cell therapy is considered especially promising because it works at a fundamental biological level, rather than merely managing symptoms. Stem cells and their derivatives (such as exosomes) have the ability to interact with the nervous system in ways that conventional treatments cannot. Instead of simply modifying behavior or neurotransmitters, stem cell-based therapies aim to support brain repair, improve neural communication, regulate inflammation, and create a healthier cellular environment that can enhance development and function.

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Addressing the Core Biological Mechanisms of Developmental Disorders

Many developmental disorders share common biological features, including altered neural connectivity, chronic low-grade neuroinflammation, impaired synaptic function, oxidative stress, and mitochondrial dysfunction. In autism, for example, studies have shown differences in brain connectivity, immune activation in the brain, and abnormal neural signaling. In Down syndrome, there is an overproduction of certain inflammatory molecules, mitochondrial inefficiency, and impaired neuronal development.

Stem cells, particularly mesenchymal stem cells (MSCs) and neural progenitor cells, have powerful immunomodulatory and neuroprotective properties. They can reduce harmful inflammation in the brain, promote a more balanced immune response, and release growth factors that support neuron survival and synaptic plasticity. This is critical because excessive inflammation in the developing brain can interfere with learning, communication, and cognitive function.

Additionally, stem cells secrete a wide range of bioactive molecules such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and other signaling proteins that promote neurogenesis (the formation of new neurons), synaptic formation, and neural network refinement. These processes are directly linked to learning, memory, and adaptive behavior—areas that are often affected in autism and Down syndrome.

The Role of Exosomes: A New Frontier in Treatment

One of the most exciting developments in this field is the use of stem cell-derived exosomes. Exosomes are tiny vesicles released by stem cells that contain proteins, microRNAs, and genetic signaling molecules capable of influencing brain cells without the need for full cell transplantation.

Exosomes can cross the blood–brain barrier, which is a major limitation for many traditional treatments. Once in the brain, they can reduce inflammation, support myelination (the insulation of nerve fibers), and enhance communication between neurons. In autism and other developmental disorders, where neural signaling may be inefficient or disrupted, this can potentially lead to improvements in attention, communication, sensory processing, and cognitive function.

Because exosomes do not divide like cells, they also present fewer safety concerns, making them an increasingly attractive therapeutic option.

Supporting Brain Plasticity and Functional Recovery

One of the key reasons stem cell therapy is so promising is its ability to enhance neuroplasticity—the brain’s capacity to reorganize itself, form new connections, and adapt in response to experience. Children and young adults with autism or developmental delays often have significant potential for improvement if their brain environment becomes more supportive of learning and adaptation.

Stem cells and exosomes help create this supportive environment by improving blood flow, reducing oxidative stress, and optimizing cellular energy production through mitochondrial support. This can make the brain more responsive to behavioral therapy, speech therapy, occupational therapy, and educational interventions, leading to better overall outcomes than rehabilitation alone.

Mitochondrial Support and Energy Metabolism

Many individuals with autism, Down syndrome, and other developmental conditions show signs of mitochondrial dysfunction, meaning their brain cells may not produce energy efficiently. This can contribute to fatigue, cognitive difficulties, and slower processing.

Stem cell therapy has been shown to stimulate mitochondrial biogenesis (the creation of new, healthier mitochondria) and improve cellular energy metabolism. By enhancing ATP production in neurons and supporting overall cellular health, stem cell-based treatments may help improve attention, endurance, and cognitive performance.

Why This Approach Is More Than Symptom Management

Unlike traditional medications that often only target specific symptoms (such as hyperactivity, anxiety, or irritability), stem cell therapy addresses multiple underlying biological factors simultaneously. It does not simply mask symptoms—it aims to improve the brain’s structural and functional foundation.

This multi-targeted effect—reducing inflammation, promoting neural repair, enhancing connectivity, and improving cellular energy—makes stem cell therapy particularly well-suited for complex developmental conditions that involve widespread neurological differences rather than a single isolated defect.

Realistic Expectations and Future Potential

It is important to emphasize that stem cell therapy is not presented as a “cure” for autism or Down syndrome. These are lifelong conditions with genetic and developmental components. However, growing evidence suggests that stem cell-based approaches may significantly improve quality of life, cognitive function, communication, social interaction, and motor skills in selected individuals.

As research advances, combination therapies involving stem cells, exosomes, neurotrophins, and personalized rehabilitation programs are likely to become more refined and effective. The future of treatment for developmental disorders is moving toward biologically informed, regenerative, and personalized medicine—and stem cells are at the forefront of this transformation.

Key Biochemical and Functional Changes After Stem Cell–Based Therapy and Their Impact on Cognition

1. Reduction of Neuroinflammation and Immune Rebalancing

One of the most consistent biochemical effects of stem cell and exosome-based therapies is the modulation of the immune response in the brain and peripheral nervous system. Many neurodevelopmental and neurodegenerative conditions are associated with chronic low-grade neuroinflammation, characterized by overactivation of microglia and elevated levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.

After therapy, there is often a shift toward a more anti-inflammatory environment. Regulatory immune pathways become more active, while excessive inflammatory signaling is dampened. This reduction in neuroinflammation decreases ongoing neural stress and prevents secondary damage to neurons and synapses. As a result, neural networks can function more efficiently, which supports improvements in attention, information processing, and learning capacity.

2. Enhanced Neurotrophic Support and Synaptic Plasticity

Stem cells and their derivatives release a broad range of neurotrophic factors, including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell–derived neurotrophic factor (GDNF). These molecules play a central role in neuronal survival, synaptic formation, and synaptic plasticity — the brain’s ability to strengthen or weaken connections based on experience.

Following therapy, increased availability of these factors supports the formation of new synapses and the refinement of existing neural circuits. This enhanced synaptic plasticity is closely linked to improvements in memory, learning, language processing, and adaptive behavior, as the brain becomes more capable of reorganizing itself in response to environmental and educational input.

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3. Improved Myelination and Neural Signal Transmission

Another important functional change involves support for oligodendrocytes and myelin repair. Myelin is the insulating layer around axons that enables fast and efficient electrical signal transmission between neurons.

Stem cell–derived exosomes and neural progenitor cells can promote the maturation of oligodendrocyte precursor cells and stimulate remyelination. As myelin integrity improves, neural signals travel more rapidly and reliably across brain networks. This translates into better cognitive efficiency, faster processing speed, improved coordination between brain regions, and clearer communication between sensory, motor, and cognitive systems.

4. Restoration of Mitochondrial Function and Cellular Energy Metabolism

Many individuals with autism, Down syndrome, and other developmental disorders show signs of mitochondrial dysfunction, meaning their neurons may struggle to produce sufficient energy. Impaired mitochondrial activity can contribute to cognitive fatigue, slower information processing, and reduced neural resilience.

Stem cell therapy has been associated with stimulation of mitochondrial biogenesis — the generation of new, healthier mitochondria — and improved ATP production. This enhances the overall energy availability within neurons, allowing them to fire more consistently, maintain synaptic connections, and sustain cognitive activity for longer periods. Functionally, this can manifest as better attention, improved endurance in learning tasks, and clearer mental processing.

5. Reduction of Oxidative Stress and Cellular Protection

Excess oxidative stress — an imbalance between free radicals and antioxidant defenses — can damage neurons and disrupt synaptic communication. Stem cells and exosomes release antioxidant molecules and activate protective cellular pathways that reduce oxidative damage.

As oxidative stress decreases, neurons become more stable and resilient. This preservation of neuronal integrity supports long-term cognitive function, protecting learning capacity, memory retention, and executive functions such as planning and decision-making.

6. Enhanced Blood Flow and Neurovascular Support

Stem cell–based therapies can promote angiogenesis, the formation of new blood vessels, and improve overall cerebral blood flow. Better circulation means more oxygen and nutrients reach active brain regions, while metabolic waste products are removed more efficiently.

Improved neurovascular support enhances brain metabolism and creates a more favorable environment for neural activity. This is associated with clearer cognitive performance, improved alertness, and better integration of sensory and cognitive information.

7. Strengthening of Neural Network Connectivity

Rather than acting on isolated cells, stem cell therapies tend to influence entire neural networks. By reducing inflammation, improving myelination, and enhancing synaptic plasticity, communication between different brain regions becomes more coordinated.

This improved connectivity is particularly relevant for higher-order cognitive functions such as language, social cognition, problem-solving, and working memory. The brain becomes more synchronized, allowing information to flow more smoothly across cortical and subcortical regions.

How These Changes Translate Into Cognitive Improvement

Taken together, these biochemical and functional shifts create a more supportive, efficient, and adaptable brain environment. Cognition does not improve because new neurons simply “replace” old ones; rather, the existing neural system becomes healthier, more plastic, and more capable of learning and adaptation.

In practical terms, this may be reflected in:

Better attention and focus
Improved learning speed and memory retention
Enhanced language comprehension and expression
Greater cognitive flexibility and problem-solving ability
Reduced mental fatigue
More stable emotional and behavioral regulation

Important Perspective

These mechanisms describe how stem cell–based therapies are thought to work biologically based on current research. The degree of cognitive improvement varies widely among individuals and depends on factors such as age, underlying condition, severity of neurological differences, and combination with rehabilitation and educational interventions.

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TREATMENT PROTOCOL DETAILS

Developmental Delay Regenerative Treatment Protocol

Developmental delay disorders are complex neurological conditions characterized by delayed cognitive, motor, speech, or social development compared with typical developmental milestones. These conditions may result from a variety of factors, including impaired neural connectivity, neuroinflammation, mitochondrial dysfunction, and disruption of normal brain maturation processes.

Traditional therapies typically focus on rehabilitation strategies such as behavioral therapy, speech therapy, and educational interventions. While these approaches support functional development, regenerative medicine aims to address the underlying biological mechanisms contributing to delayed neural development.

Our treatment protocol employs a comprehensive regenerative approach combining advanced cellular therapies, neural exosome-based signaling, mitochondrial support, and restoration of the neural microenvironment. The goal is to promote neuronal repair, improve neural connectivity, regulate neuroinflammation, and support healthy brain development.

Diagnostic Evaluation

Prior to treatment, patients undergo an in-depth diagnostic assessment to identify biological and neurological factors contributing to developmental delay.

Diagnostic Procedure	Purpose
Clinical neurological consultation and developmental history	Evaluation of developmental milestones and neurological status
Neurodevelopmental assessment tests	Measurement of cognitive, motor, and social functioning
Brain MRI	Evaluation of brain structure and identification of neurological abnormalities
Electroencephalography (EEG)	Assessment of brain electrical activity
Metabolic and mitochondrial function tests	Evaluation of cellular energy metabolism
Inflammatory and immune markers	Detection of neuroinflammation
Genetic and metabolic screening	Identification of underlying genetic or metabolic conditions

Results of these diagnostic evaluations guide the development of a personalized regenerative therapy plan.

Regenerative Treatment Components

Therapy Component	Biological Role
Mesenchymal Stem Cells (MSC)	Immunomodulation, reduction of neuroinflammation, support of neural tissue repair
Neural Progenitor Cells	Support of neuronal regeneration and enhancement of neural connectivity
Neural Stem Cell–Derived Exosomes (Neural EXO)	Cellular signaling, stimulation of neuroregeneration and synaptic plasticity
Mitochondrial Therapy / Mitochondrial Transfer	Restoration of cellular energy metabolism and support of neuronal function
Neurotrophic Growth Factors	Promotion of neuronal survival, axonal growth, and synaptic development

Each component targets key mechanisms involved in developmental delay, including impaired neuronal connectivity, mitochondrial dysfunction, neuroinflammation, and altered neural signaling.

Neural Microenvironment Restoration

A central objective of the protocol is restoring the neural microenvironment, which includes balanced immune signaling, proper synaptic communication, neuronal support cells, and extracellular matrix stability.

Disruption of these processes during early development may interfere with normal brain maturation. Regenerative therapies aim to recreate a supportive biological environment that facilitates neural growth, synaptic plasticity, and functional connectivity.

Metabolic and Neurotrophic Support

The protocol may include supportive interventions aimed at optimizing neuronal metabolism and neurotrophic signaling.

Developing brain tissue requires high levels of energy and precise metabolic regulation. Supporting mitochondrial function and neurotrophic pathways may enhance neuronal activity, improve synaptic formation, and support overall brain development.

Treatment Process

Treatment Stage	Description
Patient evaluation	Clinical assessment, neurological testing, imaging, and metabolic analysis
Personalized treatment planning	Selection of appropriate regenerative therapies
Cellular therapy procedures	Administration of MSCs, neural progenitor cells, and neural exosomes
Supportive therapies	Mitochondrial support and neurotrophic factor therapy
Follow-up monitoring	Developmental assessments, neurological evaluation, and therapy adjustment

Integrated Regenerative Approach

The key principle of this protocol is combination regenerative therapy, where multiple biological technologies act together to address the complex mechanisms underlying developmental delays.

By simultaneously targeting neuroinflammation, mitochondrial dysfunction, neuronal regeneration, and neural signaling pathways, this approach aims to support brain development, enhance cognitive and motor functions, and improve long-term developmental outcomes.

TREATMENT COST

The cost of regenerative therapy for developmental delay disorders may vary depending on several factors, including the severity and type of developmental impairment, the age of the patient, the duration of the condition, and the complexity of the clinical presentation.

Since each case is unique, our clinic follows a personalized approach, where the therapy plan is individually developed based on diagnostic findings, neurological assessments, patient history, and the biological characteristics of the neurodevelopmental condition.

The protocol may include various types of regenerative cellular therapies (mesenchymal stem cells and neural progenitor cells), neural stem cell–derived exosome treatments, mitochondrial support, and supportive regenerative procedures aimed at restoring the neural microenvironment, improving neuronal connectivity, reducing neuroinflammation, and optimizing metabolic and mitochondrial function in the developing brain.

Due to this individualized and multidisciplinary approach, the total cost of therapy typically ranges from 8,000 EURO depending on the treatment strategy and the number of regenerative components included in the program.

PUBLISHED RESEARCH

Mesenchymal Stem Cells in Autism Spectrum and Neurodevelopmental Disorders: Pitfalls and Potential Promises

A review of mesenchymal stem cells (MSC) for autism and other neurodevelopmental disorders, highlighting their immunomodulatory and neuroprotective potential.

Direct link:
https://pubmed.ncbi.nlm.nih.gov/26230216/

2. Mesenchymal Stem Cell‑Induced Neuroprotection in Pediatric Neurological Diseases

This review explores the neuroprotective mechanisms of MSCs in pediatric neurological conditions (autism, cerebral palsy, developmental delay), showing MSCs can stimulate neuronal regeneration and secrete neurotrophic factors.

Direct link:
https://pubmed.ncbi.nlm.nih.gov/38261236/

3. Exosomes Derived from Mesenchymal Stem Cells Improved Core Symptoms of Autism

This study demonstrates that MSC-derived exosomes can improve social behavior and reduce symptoms in experimental models of autism. Exosomes deliver proteins, RNAs, and signaling molecules that support neural repair.

Direct link:
https://molecularautism.biomedcentral.com/articles/10.1186/s13229-020-00366-x

4. Umbilical Cord‑Derived Mesenchymal Stromal Cell Therapy to Prevent Neurodevelopmental Disorders

This research shows that umbilical cord MSCs have neuroprotective effects and can improve neurological function in models of developmental delay.

Direct link:
https://www.nature.com/articles/s41598-023-30817-3

5. Transplantation of Mesenchymal Stem Cells Reverses Behavioral Deficits and Impaired Neurogenesis

An experimental study demonstrating that MSC transplantation can restore neurogenesis and improve cognitive and social functions in models of neurodevelopmental disorders.

Direct link:
https://pubmed.ncbi.nlm.nih.gov/28407680/

Testimonials

Patient L.P., 13. Psychomotor delay and secondary immune deficiency

The letter from the parents of the patient L.P. with psychomotor delay and secondary immune deficiency

Patient: L.P.
Age: 13
Gender: Female
Diagnosis: Psychomotor delay. Secondary immune deficiency
Country: Denmark
Date of the treatment: 21-22.06.10

We are all fine – thanks!

L. is doing very well. Her spasticity in her legs is decreasing. Her physiotherapist was amazed when checking her legs in August 2010. The quality of walking parents-assisted has improved – she is able to stand seconds longer than before – when walking she seems straighter and more stabile. When evaluated by the Belgium ABR team in August, they found her weight bearing in her shoulders when lying on the stomach has improved much more than expected. Left arm is less rigid. Standing in her standing device has improved too – she can hold her trunk much better. Everybody tells us that her technique when crawling on hands and knees looks much better and more stabile. She is still falling a lot.

Her bladder control is still improving. For the past 4-5 years L. used 5-6 diapers daily. Now she uses 3, 2 diapers only per day since August 2010 – mostly at night. When she is tired it can still be difficult for her to hold until it is time to go to the bathroom. At night there is no change. Concerning her bowel she has mostly control of it but we do see an accident at night once or twice a month. The bowel control is the same. We still see her fingers get white when it is a bit cold. Her Rayneaud syndrome is almost the same.

Her energy level has increased – she has more stamina during the day.

When evaluated at FHC she did her best ever. Her progress since January till July 24th was 115%!!!!! Her growth rate since 2003 has never been over 60%. She showed her intellectual ability very convincingly when speedreading 30 pages in 1 minute and then being able to put 5 sequences from the first chapter written on 5 pieces of paper in the right order without help at all. The book was a book written for adults. She showed her math skills in the same way and there is no doubt any longer how bright she is. Now she shows it. Before the stem cell treatment it was very difficult for her to show it in an unfamiliar environment.

Her ability to communicate nonverbally is increasing – she uses more signs than before and does it faster. She tried harder to participate in dressing herself, locking/unlocking her wheelchair, drinking of a glass independently etc.

We will have a blood test done in November and as soon we get the results you will have them. The physiotherapist will visit us November 25th. Then we will contact you again.

We are looking so much forward to see what the stem cells will bring a year from now – it is amazing what has already happened.

Best regards,
L., J. and M.

Patient O.H., 13. Developmental delay. Well-managed secondary hypothyroid

Feedback from the patients after stem cell therapy

Patient: O.H.
Gender: Female
Age: 13
Country: Denmark
Diagnosis: Developmental delay. Well-managed secondary hypothyroid
Dates of treatment: May 13-14, 2013 (4th course)

Patient: M.H.
Gender: Female
Age: 50
Country: Denmark
Diagnosis: Chronic fatigue syndrome. Remission of lumbar osteochondrosis with moderate muscle tone abnormalities.
Dates of treatment: May 13-14, 2013

Three months post-treatment, the patients wrote us the following report on their health condition.

Dear Valentina,

Things have been really good. O.’s OCD – obsessive compulsive behavior – and her anxiety has almost disappeared. Her manual skills has improved, she is now independent pulling up her pants, putting on her shirt and almost independent putting on her socks. She has improved her skills when taking a shower, washing her hair, body, putting conditioner in her hair and so forth.

She has a much more willing attitude to learn new skills and she is now trying to work on the things that are difficult for her. Before she had a very hard time being introduced to things she needed to practice. Also her transitioning has improved, she is smoothly following along and moving on to new activities. Her self-damaging behavior has decreased, she is not hitting herself with the same intensity as before. She is must more calm and cooperative and her compliance has improved in a fantastic way. She is learning new skills and improving very much every week. New sounds and better breathing and she has grown a lot.

In short I would put it this way: it has been the best month in August in all the 10 years I have being doing programs with O. I am so motivated to help her and do the program in contrast to before where is was quite tiresome to do program with O., because she sabotaged the program and was highly oppositional to all things that were introduced to her.

Her prognosis for her height was before treatment with stem cells and growth hormone 135 cm. Now the prognosis is 150 cm. And the doctors expect she can get even higher than that.

With regard to me: I have a much better life, more energy, when I do running with O. I am able to do it without getting soar afterwards. I went trough a big court case in August and I was able to focus on O.’s training right after being in the court. So I feel I am better at controlling high stress and getting it out of my system again. I also think my face wrinkles have gotten less and not as deep as before. I look more alive and I feel more alive – and better at cooping with my challenges.

Warmest regards to everybody from O. and M.

Patient A.J., 6. Sequels of hypoxic-ischemic damage of the central nervous system with psychomotor delay. Alalia. Symptomatic epilepsy with myoclonic seizures

Improvements in A.J. condition after the stem cell treatment

Patient: A.J.
Gender: Male
Age: 8
Country: Oman
Diagnosis: Sequels of hypoxic-ischemic damage of the central nervous system with psychomotor delay. Alalia. Symptomatic epilepsy with myoclonic seizures
Dates of treatment: January 21-22, 2015

I am a mother of patient A. who was treated in your centre on January 2015.

A. now completed one year and 2 month from the stem cell treatment.

He joined intensive physiotherapy programme from last November to February. He did very well in the programme. Really we didn’t imagine that he will get this much of improvements.

Now can change laying position to sitting position without our help.
He can also stand on sofa or bed side without our help.
He has a good head control.
In general all his movement has improved.

Still he is not saying any letters or words but he understands what’s going on.

We take a professional physiotherapy course and we bought all necessary stuff (like therasuit, standing frame, electrical stimulation machine and others) and we are continuing his programme at home.

I would like to know about his next treatment programme.

Thank you very much.

Patient Z.M., 2. Organic CMV-induced CNS damage with microcephaly, tetraparesis and cognitive deficit

Improvements in Z.M. condition after the stem cell treatment

Patient: Z.M.
Age: 6
Gender: Female
Country: Slovakia
Diagnosis: Organic CMV-induced CNS damage with microcephaly, tetraparesis and cognitive deficit.
Dates of treatment: November 13-14, 2015

Dear Sirs,

thank you very much for your birthday greetings for our Z. We were very pleased upon receiving it.

We would like to inform you about Z.’s progress which we have noticed:

The stem cells were transplanted in November 13-14, 2015 and since that time Z. completed four weeks of rehabilitation exercises and four horse rides (hippotherapy).

The greatest progress is in the mental and sciential area = recognition of people – she reacts through laughing or crying.

Z. began to laugh out loud when we tickle her or when we cough or sneeze.
She began purposefully nibble her fists/hands – thus she is giving a signal that she is hungry.
She grew 8 new teeth = she has already 10 teeth.
She makes noises: ej, gay, grr.
She can maintain her head up to approx. 70% and she has stronger back and limbs.
She is more mobile, tries to crawl. When I trig her feet to ground, she tries to pull herself into standing position.

It’s hard to describe the progress fully, thus we’re sending you also some video. For us, it is a very great progress forward and we are very pleased of her. Z. is also very pleased and enjoys when she manages something new, so I think that the treatment with stem cells helped her, because for these last three months she did a lot more that she failed in previous 19-20 months.

Once again, thank you very much and we stay in touch.