Autism (autism spectrum disorder, ASD) is a fairly common developmental disorder in children. According to WHO, 1 in 160 people suffer from ASD. There are various forms and manifestations of autism, this condition is incurable, but it can be corrected, thanks to which a person can be partially or completely adapted socially. These children differ not only from the majority, but also from each other. Some of them may be exceptionally gifted, but usually they develop and learn atypically, and it takes more time and effort to learn the usual skills.
NEW INFORMATION:Stem Cell Therapy Of Development Delay Diseases – Patient Reviews and Outcomes
The main areas of autism therapy are:
Medicinal – aimed no longer at treatment, but at the correction of behavior
Psychotherapeutic
Defective
The introduction of stem cells has been considered an alternative and more natural method of autism treatment for several years. Preference is given to umbilical cord blood and cells from the umbilical cord.
The mechanism of action of umbilical cord blood and umbilical cord in autism is due to the anti-inflammatory effect of cells, their ability to regulate immune processes and restore damaged parts of the nervous system. Treatment is most effective at an early age (up to 10 years) also due to the ability of cells to release active factors that stimulate the body’s own reserve recovery (paracrine effect). In young children, the recovery potential is higher and the natural concentration of stem cells in the body is greater than in teenagers or adults.
Our clinic recommends that families who are faced with the problem of autism in a child contact us.Since 2012, more than four hundreds of client families have received therapy with their own umbilical cord blood or stem cells from the material. Most of them received positive results, which were manifested in the improvement of the child’s socialization and behavior, the growth of the ability to learn, the development of speech, the establishment of normal nutrition, the development of coordination and fine motor skills. Of course, cell therapy is not a panacea, not a “magic wand”, so the best results were obtained by families who took a comprehensive approach to the rehabilitation of the child, but it was stem cells that gave a new impetus and increased the effectiveness of other methods.
The first studies of the effectiveness of cord blood in the treatment of autism began as early as 2004 at Duke University, and later the study was expanded to use mesenchymal stem cells from the umbilical cord. Today, in the USA, such studies are supported by the FDA, which makes it possible to receive structured and verified data on effectiveness.
About 130 studies of cell therapy for autism are registered on Clinical trials alone, which are taking place in well-known medical institutions around the world. The source of stem cells is one’s own or donor umbilical cord blood and cord, own bone marrow. Umbilical cord blood preparations remain the favorite, mesenchymal stem cells of the umbilical cord showed their effectiveness in second place.
OUR CLINIC’S APPROACH IN THERAPY:Stem Cell Treatment Abroad: An International Clinic with Advanced Regenerative Medicine Solutions
The results of well-known studies in the world:
In 2017, Duke University, USA proved the safety and effectiveness of using stem cells obtained at birth. And already in 2020, he provided the results of a comparison of the effects of his own umbilical cord blood and donor blood. Both sources have shown efficacy, with 70% of children having significantly improved social and communication skills over a year compared to a control group not treated with cord blood.
The use of mesenchymal stem cells from donor umbilical cords to treat autism in children has been investigated at the Stem Cells Institute, Panama. Results were assessed 13, 25, 49 and 89 weeks after the administration of the cells and showed significant progress in communication, sociability, awareness and behaviour.
The Sutter Institute, USA studied the effect of the child’s own umbilical cord blood.The main findings were significant positive changes in the children’s behavior, which were noted by all 60 families, as well as the safety and affordability of the treatment procedure.
The research at Shandong Jiaotong Hospital, China was conducted with the involvement of 37 children aged 3 to 12 years. Donor stem cells from umbilical cord blood and umbilical cord were used. Social interaction, reaction to visual images, sociability were assessed. Results using cells from both sources were excellent or good:
In 8 out of 9 children who received mesenchymal stem cells from the umbilical cord (89% efficiency)
In 7 children out of 14 who received stem cells from donor umbilical cord blood (50% effectiveness)
1 out of 14 children in the control group that did not receive stem cell treatment
Research by Vinmec Research Institute of Stem Cell and Gene Technology Hanoi, Vietnam was conducted from 2017 to 2019. Used stem cells derived from umbilical cord blood in combination with an educational intervention for children with autism spectrum disorder. Thirty children who met the criteria were selected. Mononuclear cells were isolated and then injected intrathecally. The same procedure was repeated after 6 months. Autism spectrum disorder (autism) severity was significantly reduced, with the median CARS score decreasing from 50 (range, 40-55.5) to 36.5 (range, 33.5-38.5) (P < 0.05). Adaptability increased, and the average Weinland Adaptive Behavior Scale score increased from 53.5 to 68.5. Social communication, language, and daily skills improved markedly within 18 months of transplantation.Conversely, repetitive behaviors and hyperactivity were markedly reduced. Autologous mononuclear cell transplantation combined with behavioral intervention was safe and well tolerated in children with autism.
The results obtained by our clinic in Kyiv together with the Family Cord Blood Bank:
During the period from 2018 to the present, 423 children with a diagnosis of autism spectrum disorder were treated.
The age of the patients was from 3 years. up to 10 years
The infusion of cells from umbilical cord blood was carried out in a dose calculated according to the weight of the patients and the presence of concomitant diseases. 20 cases are family use of umbilical cord blood from younger brothers and sisters, others – autologous use. Before the procedure, the patients underwent a complex of general clinical laboratory examinations (general and biochemical blood tests, coagulogram), as well as a comprehensive study of immunity (immunogram).
For a better effect, the procedure was repeated after 6 months at the same time as a re-examination. Patients were evaluated 3 months, 6 months, and 12 months after cell administration.
According to the results of the evaluation after 1 year, improvement on the scales of assessment of behavioral and cognitive disorders was observed in 401 of 423 patients, that is, in 78.2%, in patients (10.3%) there were no significant changes, in 11% of patients a pronounced positive effect was observed , almost complete socialization (children go to regular school, with a delay of 1-2 years).
In this group of patients, convulsive readiness according to electroencephalography (EEG) was detected in (63%). After 2 applications (after 1 year), a 92% decrease in convulsive readiness was observed, 53 patients were able to stop taking anticonvulsant drugs.
No side effects were detected. In 81% of patients, general weakness was observed in the first 24 hours after the infusion. 52% of children had a temperature reaction (up to 38.8-39.2°C), which was corrected by symptomatic treatment (ibuprofen, paracetamol).
In the future, in order to enhance the effect of combined use, it is planned to use the infusion of umbilical cord mesenchymal stem cells together with hematopoietic stem cells of umbilical cord blood.
INTERESTING TO READ: Great results of autism stem cells treatment
There is no doubt that in the coming years, we will witness a gradual expansion of the use of stem cells in the field of treatment of diseases of the nervous system, such as autism spectrum disorder. It is safe to say that stem cell therapy is a promising new treatment tool and has potential therapeutic targets based on their remarkable regenerative abilities and immunomodulatory effects. One of the most important aspects is the long-term safety and effectiveness of stem cell therapy for autism.
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