With the help of stem cell therapy, the progression of the disease DEMENTIA can be slowed down and regressed. The success of treatment is proportional to the patient’s age, duration of the disease and the patient’s condition.
Treatment of the disease DEMENTIA with stem cells is recognized as a new method that scientists are working on, but there are already enough clinical trials that show the effectiveness of using stem cells in therapy.
Stem cells have the ability to turn into brain cells when they come into contact with damaged brain cells. Therefore, stem cells are used in the treatment of DEMENTIA.
The number of cells to be injected is determined depending on the age and weight of the patient. Treatment can be carried out in 3 sessions with an interval of 45 days or in 3 consecutive days.
What is dementia?
Dementia, commonly known as mental decline, is a state of inadequacy of a person’s mental functions, such as memory and language abilities, abstract thinking and judgment, due to illness.
Dementia is the most common cause of disability in people over 60 years of age, and its incidence increases as life expectancy increases. Although the risk of dementia is 5% at age 65, the risk doubles every 5 years to 40-50% over age 85. Forgetfulness is known to be the most common complaint in older people and is often seen as a natural result of aging, but forgetfulness in older people can have many medical causes. Dementia, which is the most common cause of mental decline, is one of the important causes of forgetfulness in older people.
There are 200 different types of diseases known to cause dementia because they weaken the brain.
What are the symptoms of dementia?
Initial symptoms of the disease;
Memory problems, forgetfulness and memory loss.
Difficulty performing routine activities.
Difficulty finding the right words
Sudden mood swings
Apathy is indifference, lack of morale and lack of self-confidence.
Difficulty doing and performing normal daily tasks.
Confusion, inability to remember faces and names of people.
It’s hard to follow stories and events.
Poor sense of direction, I get lost all the time.
Repetitive behavior: Asking the same questions or repeating the same things over and over again.
Incompatibility with change, forgetting why they are doing things, and panicking.
Mental regression
It is difficult to find words and remember the names of objects.
Difficulties in calculations and working with numbers.
Causes of dementia
Cognitive losses such as forgetfulness may occur due to advanced age. This age-related condition occurs as a result of damage to nerve cells in the brain in old age and is not dementia. Thyroid disorders such as hypothyroidism, anemia, vitamin B12 and folic acid deficiency, and some other diseases are some of the causes of forgetfulness in older people.
Complaints of forgetfulness in older adults should be taken seriously. The cause of forgetfulness should be determined after various assessments. Because some of the problems and diseases that cause dementia can be treated, the progression of the disease can be slowed. For example, problems such as metabolic disorders, depression, drug side effects and drug misuse can be prevented. Therefore, early identification of the problem causing dementia is very important.
Dementia treatment
The success of treating dementia depends on the source and severity of the disease causing the problem. Detailed information to the patient and his relatives, providing them with the necessary support is very important for recovery, as well as for the quality of life. Even if there is no specific cure, some new medications introduced in recent years reduce symptoms of dementia and slow the progression of the disease.
For vascular dementia, which can cause blood to clot in the brain, treatment is aimed at preventing further blood clots from forming. Patients with dementia and their families should be informed about the disease so that they can take precautions against future problems.
Treating dementia with stem cells
Stem cells have the ability to turn into brain cells when they come into contact with dying brain cells, in which case they are used to treat dementia.
The number of cells to be injected is determined depending on the age and weight of the patient. Treatment is carried out using mesenchymal stem cells (derived from umbilical cord, neural crest).
The treatment protocol is precisely determined depending on the patient’s condition, and a different protocol may be used for each patient. The most obvious and lasting effect of treatment was obtained at the initial stage of the disease, when neurological and mental symptoms appeared (in 90% of cases). Positive results were also obtained in patients with organic brain lesions (atrophy of the frontoparietal lobes).
As a result of the use of stem cells in patients with severe mental disorders, the quality of life of patients (general condition, sleep, appetite, etc.) has significantly improved.
Why you should pay attention to stem cell treatment:
Stem cell therapy is a unique approach to treating disease. It involves the systemic introduction of mesenchymal stem cells into the body through intravenous and endolumbar injection. When administered in large quantities, these stem cells can detect and eliminate inflammation in the body. This unique property of stem cells potentially makes them an effective treatment for dementia of various etiologies.
Stem cell therapy can:
Regenerate neurons
Improve overall functional recovery
Replace damaged cells with healthy cells
Research shows impressive results
Research shows that stem cell therapy can improve brain health by reducing swelling, repairing damaged nerve cells and improving cognitive function in people with mild to severe dementia and other related complications
In particular, mesenchymal stem cells (MSCs) have been found to support the immune system and reduce inflammation. According to a 2020 study, MSCs can suppress inflammation in different ways: by enhancing anti-inflammatory factors or suppressing pro-inflammatory factors. In addition, MSCs can also suppress immune responses through direct contact with cells.
Mesenchymal stem cells (MSCs) are activated by inflammatory mediators and release paracrine factors and microvesicles into the bloodstream. These molecules reach the site of injury and, together with previously recruited MSCs, modulate the progression of inflammation and promote the repair of brain tissue.
Mesenchymal stem cells (MSCs) can promote survival, increase metabolic activity, and help rescue brain cells.
What makes stem cell therapy for disease so exciting is its ability to stop disease progression and regenerate damaged neurons, rather than simply slow it down or manage symptoms.
In recent years, stem cell therapy has emerged as a promising potential treatment for dementia. Stem cells can differentiate into various cell types, including brain cells, potentially replacing damaged cells and improving cognitive function. Thus, stem cell therapy is being studied with the goal of slowing or stopping progression and perhaps even reversing some of its effects. Mesenchymal stem cells (MSCs) are a type of stem cell that can differentiate into several cell types.
Immunomodulatory and anti-inflammatory effects of therapy were observed due to increased neuroprotection and decreased activity of pro-inflammatory cytokines. Another significant way in which MSCs participate in tissue repair is through the secretion of extracellular vesicles and microvesicles, which have been extensively studied.
Research has shown that MSCs may help reduce the accumulation of Aβ plaques in the brain and improve cognitive function. MSCs can do this by secreting anti-inflammatory and antioxidant molecules that can reduce inflammation and oxidative stress in the brain. Additionally, MSCs can differentiate into neurons, which can help replace damaged or lost nerve cells in the brain.
This approach could potentially provide a new therapeutic option for this debilitating disease.
Benefits of Stem Cell Therapy
Mesenchymal stem cell (MSC) therapy for dementia has several potential benefits, including:
Reduce inflammation: MSCs can secrete anti-inflammatory molecules that can help reduce inflammation in the brain (neuroinflammation). Chronic inflammation is associated with disease development and progression, and reducing inflammation may help slow disease progression.
Stimulate tissue repair: MSCs can differentiate into various cell types, including neuron-like cells, which can help replace damaged or lost nerve cells in the brain. This process could potentially help restore cognitive function.
Reducing the accumulation of amyloid plaques: Research has shown that MSCs can reduce the accumulation of beta-amyloid protein, a hallmark of dementia. This could potentially slow the progression of the disease and improve cognitive function.
No risk of complications: MSCs are known to have low immunogenicity, meaning they will not be rejected by the recipient’s immune system. This makes MSC therapy safe and viable.
In conclusion, dementia is a complex neurodegenerative disease that affects millions of people around the world, and it is a serious condition that requires ongoing research and treatment.
As research continues, family members and caregivers need to be aware of the early symptoms of dementia and seek medical help for their loved ones.
Early intervention can help slow the clinical decline of the disease and improve the quality of life of those affected. Treatments are available to treat symptoms such as memory problems and agitation during moderate to severe stages of the disease. With continued research and a better understanding of the underlying disease mechanisms of dementia, we may one day find a cure and improve the lives of millions of people around the world.