Stem cell therapy for Alzheimer’s disease

Stem cell therapy for Alzheimer’s disease

Alzheimer’s disease is a severe neurodegenerative pathology and the most common form of dementia (dementia). It was first described in 1906 by the German psychiatrist A. Alzheimer, after whom it was later named.

As a rule, this disease is found in people over 65 years old and extremely rarely at a younger age. It proceeds in each specific case in different ways, however, a number of general symptoms are always observed. In the early stages, as a rule, there are disorders of attention and memory for recent events, then, as the pathological process progresses, confusion arises, the patient becomes irritable and even aggressive, there is frequent mood swings, the ability to speak and understand what has been said suffers, long-term memory and As consciousness fades, the patient’s general self-elimination from affairs occurs.

As an option for the complex treatment of Alzheimer’s disease, cell therapy, which has already proven itself quite well in this pathology, is now used, aimed at slowing down the progression of the disease. Its effect is especially noticeable in the early stages, when it is almost completely possible to stop the further development of clinical symptoms. In the presence of severe mental disorders, the result of treatment is reduced to ensuring an improvement in the patient’s quality of life, namely: his general well-being, appetite, sleep.

The situation is complicated by the fact that sometimes Alzheimer’s disease develops latently, not manifesting itself in any way for a long time before clear signs of pathology become noticeable and a diagnosis is made. In addition, the first objective manifestations are often mistakenly associated with old age or explained by the influence of stress or overwork. All this makes it impossible to carry out treatment with stem cells at the initial stages of pathological changes in the brain, and, therefore, to obtain better results.

In terms of preparation for cell therapy, the patient is carefully examined in order to establish the extent of the lesion and exclude contraindications. Then the bone marrow is collected for subsequent transplantation. The culture of the withdrawn stem cells is grown on special media for two to three weeks and differentiated in the neuronal direction. The cells prepared in this way are injected intravenously or endolumbar, that is, directly into the spinal canal, to the patient. Usually three such procedures are prescribed, the interval between which is on average from three to six months (depending on the specific clinical indications).

In most cases, thanks to the timely started cell therapy, it is possible to significantly slow down, and sometimes completely stop the further development of Alzheimer’s disease. In the most difficult situations, this treatment is used to prolong the period of preservation of sanity and the patient’s ability to self-care, that is, his independence from family members or medical personnel.

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