Type 1 diabetes, which occurs when the pancreas does not produce enough insulin to control blood glucose levels, is a disease that currently has no cure and is difficult for most patients to cope with.
B- cells use:
There’s a lot of focus now on developing a promising approach to treating it: using stem cells to create insulin-producing cells (called beta cells) that can replace dysfunctional pancreatic cells.
Functional beta cells derived from human pluripotent stem cells, i.e. from embryonic material
ANALYSE NEW PROTOCOL OF THERAPY: Stem Cells Treatment for Diabetes Type 1 and Type 2
“Stem cells are an extremely promising approach for developing many cell-based therapies, including more effective treatments for type 1 diabetes.” This method of producing large numbers of safe and functional beta cells is an important step forward.”
Producing beta cells from fetal material in the laboratory is not new. With current methods, only 10 to 40 percent of cells become beta cells. By comparison, methods used to create nerve cells from embryonic material have a yield of about 80 percent.
Stem cells have a unique property, so stem cell therapy is very effective in the treatment of type 1 diabetes: stem B cells are transformed into pancreatic cells responsible for insulin production, and damaged tissues are restored. The function of the pancreas is normalized, and there is a significant improvement in the condition. In addition, stem cell treatment strengthens the immune system and restores the cardiovascular system. This is especially important for patients with diabetes, since this disease is often complicated by serious circulatory problems, especially in the small vessels of the extremities.
Clinical experience:
Clinical experience shows that type 2 diabetes can be treated with stem cells much better and faster than type 1 diabetes. We cannot say that stem cells are able to increase the production of necessary enzymes and specific proteins in all tissues of a patient with type 2 diabetes, however, the results of treatment rather confirm this possibility than refute it – up to 85% of patients after treatment with stem cells live without diabetes for more than 10 years . However, it should be noted that this result is observed only in those patients whose insulin production is not yet impaired (C-peptide levels are within normal limits). Once absolute insulin deficiency is added to the pathogenesis of the disease, curing a patient with type 2 diabetes becomes much more difficult.
READ MORE ABOUT CASE STUDY: Diabetes Type 1 ; Type 2 – Stem Cells Therapy : Case Study
It is quite natural that after achieving proper control over the level of glucose and glycosylated hemoglobin, even in those patients who did not get rid of diabetes due to the addition of absolute insufficiency of insulin production, such serious complications as atherosclerosis, fatty infiltration of the liver, arterial hypertension, diabetic nephropathy and diabetic foot do not develop.
But patients with such complications should not despair. Organ-specific progenitor/stem cells are also successfully used to treat complications of diabetes mellitus of any type.
Langerhans progenitor cells use:
In addition to B-cells, in our practice we use islet cells of the pancreas, or islets of Langerhans – accumulations of endocrine cells in the pancreas, mainly in its tail part. 60–80% of the islets are beta cells, which secrete insulin, and 15–20% are alpha cells, which secrete its antagonist hormone, glucagon. These cells are introduced as progenitor cells from fetal material, where they can easily integrate into the patient’s pancreas without causing an immune system reaction
In adults, cells of the islets of Langerhans are limited in their proliferative activity. Therefore, progenitor cells that would help maintain the pool of β-cells during homeostasis and regeneration are taken specifically from embryonic material.
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Cell therapy helps improve the course of the disease, namely:
- reduce the need for insulin-containing drugs;
- significantly reduce the risk of complications (diabetic foot, erectile dysfunction, cardiomyopathy, gastroenteropathy, etc.);
- restore damaged organs and tissues if complications have already occurred;
- normalize blood pressure due to the regeneration of vascular endothelium;
- restore blood circulation in the extremities and reduce the risk of ischemia.
- In general, the use of stem cells helps to significantly improve the quality of life of patients with diabetes of any type.
The results of complete cure of patients with type 2 diabetes are significantly higher than with type 1 diabetes, but the prognosis of treatment results is based on the current condition of the pancreas, the degree of damage and related complication
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