In modern medicine, we are increasingly trying to use the most accurate and personalized medicine. What could be more personal than your own stem cells, which enter the target organs and contribute to the resumption of the function of their own organs.
Stem cells in the treatment of male infertility
Very interesting and important is the treatment of male infertility by the introduction of autologous stem cells in non-obstructive azoospermia, i.e. situations when the testicles do not completely produce spermatozoa, since they lack spermatogenic epithelium. In some cases, the introduction of stem cells into the testicular parenchyma can restore sperm production, restore sensitivity to follicle-stimulating and luteinizing hormones, improve testosterone synthesis, which can restore lost fertility and improve sexual function.
READ MORE ABOUT NEW Advanced Regenerative Therapy Protocol for Male Infertility
Every 7th man of reproductive age suffers from infertility. Researchers from the University of California (San Diego, USA) have proposed a new method for culturing spermatogonial stem cells (SSCs) in the laboratory. This will allow in the future to introduce CCK therapy into the practice of treating male infertility.
What are spermatogonial stem cells? This is one of the types of stem cells, which in the male body underlies the process of spermatogenesis. In fact, they are the progenitor cells of spermatozoa. They are extracted from the testicles of a man and cultured in the laboratory until they reach the state of mature sperm. After that, they can be used for in vitro fertilization.
Until recently, spermatogonial stem cells have been difficult to identify among other cells in the testes of a man. Scientists from the University of California used a single-cell RNA sequencing method to accurately determine the type of cells. They also developed a reliable method for cultivating CSCs. The results of the experiments were published in the journal Proceedings of the National Academy of Sciences.
Spermatogonial stem cells, according to the researchers, rapidly divide and mature, and CSC therapy will allow men even older than 65 to become fathers.
Stem cells are a modern innovative and effective method of treating many diseases, including the treatment of male infertility. The use of spermatogonial stem cells (SSC) in the treatment of male infertility does not raise ethical or moral problems.
Successful experiments with the use of stem cells in the treatment of infertility in men allow:
stimulate spermatogenesis;
increase the immune function of the body;
improve sexual function in men;
improve libido;
normalize the neuroendocrine functions of the body;
Important! Studies have shown that healthy spermatogonial stem cells (SSCs, or SSCs) lead to sperm regeneration and maintenance of male fertility. Spermatogonial stem cells (SSCs) are derived from primary germ cells (PGCs) during embryonic development and injected into the seminiferous tubules of male testicles, allowing the production of sperm of sufficient quality prior to fertilization. Spermatogonial stem cells are self-regenerating and can produce numerous progenitor cells that can differentiate into sperm over a lifetime. In humans, spermatogonial stem cells are responsible for the continuous production of male sperm. Spermatogonial stem cells are located in the basement membrane, which supports the seminiferous tubules of spermatogenesis. In addition, CSCs are the only stem cells that can pass on paternal genetic information to offspring.
Azoospermia Treatment with Stem Cells: Patient Case Study
One more of the success case of azoospermia treatment:
Premature ovarian failure is a complex disorder that can lead to varying degrees of infertility. Recently, mesenchymal stem cell (MSC) therapy and its progenitor cells such as exosomes, 3D organoids, receptor cells have been introduced as new treatment strategies. MSC therapy has been shown to improve ovarian function. Stem cell therapy can potentially reverse the diminished ovarian endocrine function and restore fertility.
According to the available data, the success rate of stem cell therapy for ovarian rejuvenation is approximately 35 to 67%.
However, it is important to note that this is just an estimate, and the actual success rate may vary depending on the individual patient’s circumstances.
OBSERVE MORE INFORMATION Stem Cell Therapy for Female Infertility: Ovarian Rejuvenation and Activation Before and After 40
Here are some reviews about stem cell treatment of female infertility.
Hanna ( Austria, Vienna) /Age: 40 years
Endometriosis, structural defects of the tubes or uterus, adhesions and obstacles, in which few people wanted to even try to solve the problem with conception. I underwent full treatment at the clinic in 2020, the procedures were performed easily, without complications and side effects. After 2 months, the success rate in increasing the quality and / or quantity of follicles in the ovary is 67%, before therapy, my rates were from 28-32%. We took the eggs for IVF.
Yulia, 43 years ( Slovenia), 2019
One day my husband was doing research and came across an article about ovarian rejuvenation treatments. My husband and I thought this might be the answer to our prayers for a baby. Ovarian rejuvenation involves the use of injections of donor stem cells. This process helps to increase a woman’s egg supply, increasing the chances of getting pregnant naturally with your partner. I had the procedure in December 2019. . I got my period 10 days after the procedure, My husband and I made love after my period and within 1-2 weeks my gynecologist told us we were pregnant! We now have a beautiful baby girl, We are forever grateful and blessed for the entire procedure and God’s grace. I would recommend this procedure to any woman over 35 who has gone through fertility treatments that have failed cycle after cycle. Ovarian rejuvenation literally rejuvenates your eggs and makes it more likely to conceive naturally.”
Mataj family ( USA) /Age: 39 years( F), 44 years ( M)
I never imagined how difficult this period of constant trying and failing would be. My wife and I have been through a lot in the past few months, having been trying to conceive for a long time, I thought we might have problems. We started seeking medical help and soon my wife underwent many tests and all showed excellent health indicators. I was worried and wanted to seek further medical help but none of them could reveal the cause of this case. Then I came to know about Stem Cell and was ready to accept their treatment. After coming here with my wife, we underwent many medical tests and were eventually under the supervision of a doctor to manage lifestyle changes that promote fertility. My wife, who used to smoke occasionally, was asked to quit and I was asked to quit alcohol. With their therapy, we were able to see changes in a short time as our bodies began to heal. I request anyone who witnesses such symptoms to seek medical help as soon as possible
Benitez Family ( Canada) /Age: 38 years (F), 42 years ( M)
Me, Mark and my wife Ollie have been trying to have a baby for quite some time, we are originally from Canada, and have failed every time. I was a big proponent of medical help, but my wife was not willing to do so. After much persuasion, she was finally ready to seek medical help and was diagnosed (PCOS). We were scared, and after a while I was able to cope with several medical orders that were pointing us in the same direction. While searching for medical therapy, I learned about Stem Cell and asked my wife for approval to schedule an appointment. Thanks to their therapy, we were able to eliminate the inflammation in the ovaries, remove fibrosis, and improve the patency of the tubes, and are now trying to conceive on our own. Doctors estimate our chances as high.
Vejthani Family: Wife Siripan Saenanik (42) and her husband (62). 2018.
A short interview with the family:
Q: When did you know that you have infertility problem?
MOM: I got married 13 years ago. However, 2-3 years ago, I just wanted to have a baby and tried to have a baby naturally but failed. Due to our age, having a baby is not that easy. We tried all the ways, searched information on the internet but as before, unsuccessfully. Moreover, when I found out that I have uterine fibroids, I went to consult a doctor to find out that I have infertility problem.
Q: Have you ever planned to have a baby?
MOM: We have a factory in Pathumthani so we both were worried about our jobs, especially in 2011 when there was a flood, so we did not think about having a baby at all. But when things started to improve, we started to feel ready to have a baby.
Q: How long did it take you to decide to have the treatment?
MOM: Not that long, because the doctor said that the older we get, the harder it will be. So I decided to have the treatment right away.
Q: How did you feel during the treatment?
MOM: I was worried because the doctor told us that some people in our situation have to have the treatment several times. However, I wanted to try. After the cell treatment, on the 3rd cycle I already had one strong egg out of 8. And we extracted it. Later we did IVF – and now we have a beautiful daughter. It was a fantastic attempt, because in one go we achieved incredible success.
Josephine ( 43 years, USA), 2021
Hello
I came exactly a year ago for stem cell treatment… Six months later I received a positive pregnancy test.I was waiting for the second trimester ultrasound to tell you the good news (before that I was afraid of another miscarriage).I am currently 22 weeks pregnant and we are expecting a baby boy in early December. Very excited, but still a little anxious.
We would like to thank you for this work that could help Mother Nature with the “old lady” 43 years old (low AMH).
Best wishes”
Bisma 41 years ( Poland), 2022
“Just had a fertility scan and the doctor was shocked by what he saw. No matter what you did, my right ovary has eight follicles. The left, which is half the size and has never worked, seems to be working at 50% and he saw four small follicles. When I get the results, including blood, I will forward them to your team.
Thanks again.
Sara, 40 years ( Israel), 2022
I will take the opportunity to email you. Hope you are doing well and all is well. We did the FSH and WE tests in 4 months. The results look promising! FSH- 8.4
Awaiting further advice from the doctor on how to proceed.
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